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Anticarbohydrate Antibodies - Paul Kosma - Springer, 2016
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Anticarbohydrate Antibodies
From Molecular Basis To Clinical Application
Edizione Inglese di Paul Kosma (a cura di), Sven Müller-Loennies (a cura di)
Editore: Springer Vienna
EAN: 9783709148358
ISBN: 3709148359
Pagine: 456
Formato: Paperback
Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite
From Molecular Basis To Clinical Application
Edizione Inglese di Paul Kosma (a cura di), Sven Müller-Loennies (a cura di)
Editore: Springer Vienna
EAN: 9783709148358
ISBN: 3709148359
Pagine: 456
Formato: Paperback
Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite
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